How does prior immunity affect recall responses to influenza?
Veronika Zarnitsyna, Ph.D.
Emory University
Unlike laboratory mice, humans are not immunologically naïve, and we would like to understand how prior history of influenza infections and vaccinations will affect the responses to the vaccines and new infections. Original Antigenic Sin (OAS) describes the observation that antibodies to the first encountered influenza strain dominate following infection with new drifted strains.